A Pharmacist’s Guide to Microdosing

Over 1 in 5 adults are receiving treatment for their mental health, yet many are still left asking: “Why am I not feeling better?”

With approximately 50 percent of people not fully responding to antidepressants, more individuals are exploring alternatives like microdosing in search of a new solution and a potentially different relationship to their mental health.

Both community experiences and emerging data reflect this shift. A recent report found that an estimated 8.4 million American adults have microdosed psilocybin, with mental health as the primary motivation.

With the increase in microdosing, the uncertainty around its clinical effectiveness, and as it exists in a legal gray area often with limited clinical guidance, many people are now having to navigate the risks on their own – especially when layered onto existing medications and health conditions.

So what does it actually mean to microdose safely when medications are part of the picture?

📣 Join Our Live Webinar

Join Microdosing Collective and Third Wave for a live webinar with Ben Malcolm, PharmD, MPH, Psychopharmacology Consultant and Founder of Spirit Pharmacist who has spent years helping individuals navigate the intersection of mental health medications and psychedelics with a safety-first, evidence-informed approach.

📆 Thursday, May 21st, 2026
⏰ 12:00 PM PST | 3:00 PM EST
💬 60 minutes with a live Q&A
💻 Online | Free to attend

Can’t make it live? Register anyway and we’ll send you the full recording!

What We’ll Explore:

• The most common microdosing vs. psychiatric drug interactions including SSRIs, SNRIs, stimulants, and more

• Key contraindications and who should avoid microdosing or proceed with caution

• What current research, pharmacology, and real-world data suggest and where gaps still exist

• Potential side effects, blunted effects, or unexpected responses

• How to think about microdosing through a harm reduction lens

• Live audience Q&A with Ben

If you are taking medications, thinking about tapering, exploring microdosing, or guiding others through it, this session will help you move forward with clarity and a safety-first approach.

🍄 Join our Giving Circle

If you’ve benefited from microdosing, or believe in a future where people can legally and safely access it, we invite you to become a monthly supporter.

Our Giving Circle makes it easy to support microdosing legalization through small, consistent contributions. Giving Circle has partnered with impactful nonprofits like Selena Gomez’s Rare Impact Fund, and we’re grateful for their support as we grow the microdosing movement.

- With love from team Microdosing Collective 🍄

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DISCLAIMER: This newsletter is intended for educational and informational purposes only and should not be considered a replacement for professional medical advice. Always consult your healthcare provider before making changes. The Microdosing Collective does not promote the use of any illegal substance. Please be aware that the use, possession, and distribution of psychedelic substances are illegal in many countries and could lead to legal consequences.